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Low ag ratio causes9/22/2023 ![]() ![]() Categorical variables were presented as frequencies or percentages. ![]() Continuous variables were presented as median or mean ± standard deviation (SD). The laboratory parameters, including leukocyte, creatinine, albumin, and globulin, were measured according to standard methods in the clinical laboratory of the First Affiliated Hospital of Wenzhou Medical University.īaseline data of patient clinical characteristics were descriptively summarized. Fasting blood samples were collected after overnight fasting on the first morning after admission for all patients. The other subtypes included cardioembolic infarction, small-artery occlusion (lacunae), cardioembolic infarction, stroke of other determined etiology, and stroke of undetermined etiology. The patients with AIS were etiologically classified into large artery atherosclerosis and other subtypes with the trial of ORG 10172 in acute stroke treatment (TOAST) classification criteria. The NIHSS score, which reflected stroke severity, was evaluated by at least two neurological physicians upon admission to the neurological ward. Depending on the conclusions of the dysphagia evaluation, ordinary diets, semi-liquid diet, viscous paste meal, and nasal feeding were prescribed to patients, respectively. Stroke-associated pneumonia was confirmed using the modified Centers for Disease Control and Prevention criteria for hospital-acquired pneumonia during the first week after stroke by combining clinical, radiographic, and laboratory markers of respiratory tract infection. ![]() Sociodemographic and clinical characteristics of AIS patients were obtained from electronic medical records, covering age, gender, body mass index (BMI), hypertension, diabetes, atrial fibrillation (AF), smoking history, drinking history, dysphagia, National Institutes of Health Stroke Scale (NIHSS) score ( 10), stroke subtype (TOAST classification) ( 11), and laboratory indicators (leukocyte, creatinine, albumin, and globulin). The present study aimed to explore the association between A/G and SAP, helping physicians identify those AIS patients at high SAP risk and providing more accurate guidance. To our knowledge, the significance of the A/G in SAP remained unknown. Besides, a lower A/G was an independent risk factor in AIS patients with intravenous thrombolysis for a poor outcome at 3 months ( 4). A meta-analysis of 3,496 lung cancer patients indicated that those with a low A/G were more likely to have a worse prognosis with shorter overall and disease-free survival than those with a high baseline A/G ( 9). Prior research put forward A/G as an independent risk factor for survival in elderly individuals with chronic obstructive lung disease who had an acute exacerbation ( 8). Different disorders, including cancer, infection, autoimmune disease, and stroke, are associated with A/G abnormalities ( 4– 7). Thus, early identification of pneumonia risk factors may contribute to more effective SAP prevention and reduced mortality and disability.Īlbumin to globulin ratio (A/G), a composite biomarker of two major serum elements, indicates inflammation and nutrition status ( 4). In patients with AIS, stroke-associated pneumonia (SAP) has been proven to be associated with a poor functional outcome and an increased risk of death ( 3). Acute ischemic stroke (AIS), a life-threatening neurological disorder, is one of the leading causes of mortality and disability worldwide ( 1, 2). ![]()
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